Senior Research Scientist
The Position
Novo Nordisk Research Centre Oxford (NNRCO) is recruiting for a position in one of its Data Engine Teams within the Target Discovery Engine (TDE). We are looking for a candidate with experience in cell biology and high-throughput screening to execute target identification and validation screens and deliver robust data packages to enable target progression. You will work across multiple teams spanning expertise in biology, technology platforms, assay development, data science and IT to enable scaled target discovery using pooled CRISPR and arrayed siRNA/ CRISPR approaches.
Key responsibilities will include enabling automation of new functional/ phenotypic cell-based assays, execution of scaled target identification/ validation campaigns, performing data analysis and interpretation, and communicating results to key stakeholders.
Moreover, you will:
- Propose and implement new experimental methodologies and enabling technologies for scaled data generation to support prioritization of targets.
- Work independently as well as in team settings and train colleagues within your area of expertise.
- Work with external and internal IT colleagues and vendors to enable end-to-end IT integration for process visibility, streamlined operations and data tracking.
Qualifications
We would like to hear from you if you fit any of the criteria we have listed below:
- PhD in natural science with relevant post doc/industry experience. Research experience in cardiometabolic disease area is valuable.
- Experience executing a large no. of high-throughput screens using primary cells or cell lines and performing data analysis.
- Experience using platform technologies to support target discovery, eg: flow cytometry, lab automation systems, high-content imaging, NGS.
- Experience in CRISPR, cell line development, siRNA/ guide RNA transfection, RTqPCR, immunostaining, HTS assays.
- Experience developing and validating automation methods and optimizing pipetting performance to achieve precise liquid transfer.
Furthermore, we see that you have attention to detail, exceptional organizational and communication skills as well as the ability to work on projects in parallel. You hold a diligent attention to health and safety requirements, system cleanliness and maintenance. You are a team player and self-starter and are strongly motivated to explore new ideas and methods to drive innovation for the benefit of patients.
About the Department
Novo Nordisk Research Centre Oxford (NNRCO) is one of Novo Nordisk’s Global Drug Discovery research sites focused on biology and target discovery across the broad spectrum of cardiometabolic disease in Oxford, United Kingdom. Our location in the heart of the University of Oxford medical campus enables two-way collaborations with some of the best medical scientists in the world.
Our mission at the Target Discovery Engine (TDE), Oxford is to identify and validate novel drug targets by efficiently developing scalable approaches, fuelled by data and digital solutions. We utilize human-centric in vitro screening approaches aligned with our therapeutic area and portfolio requirements with the aim to identify targets and key biology to discover new disruptive therapeutics.
The Target Accelerator Group within the TDE has specialists and staff scientists in its sub-teams of Technology Leaders, Assay Architects and Data Engines. We are a dedicated, collaborative team of scientists working with a variety of advanced technologies, including automation and screening, high-content imaging, single-cell sequencing, CRISPR editing, proteomics and peptidomics. We collaborate very closely with the Discovery Biology Group, continually working on strategies to develop new disease models to fuel targets for unmet medical need. Together, we share a passion for translational research and a desire to discover new scientific paths to improve the lives of patients.
Working at Novo Nordisk
We are a proud life-science company, and life is our reason to exist. We’re inspired by life in all its forms and shapes, ups and downs, opportunities, and challenges. For employees at Novo Nordisk, life means many things – from the building blocks of life that form the basis of ground-breaking scientific research, to our rich personal lives that motivate and energise us to perform our best at work. Ultimately, life is why we’re all here - to ensure that people can lead a life independent of chronic disease.
Contact
Please apply to the role via our online platform as unfortunately we don’t accept directly sent CVs.
Deadline
Please apply before 6th February.
The Talent Acquisition team will engage with applicants on an ongoing basis, so apply as soon as you can!
We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.
At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.
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